Stereoselective synthesis through remote functionalization

Transition-metal-catalysed alkene isomerization is instrumental to remote functionalization processes, in which a chemical transformation induced at position from the initial reactive site. The dynamic nature of isomerization, crucial for such transformations, often leads substantial difficulties controlling stereochemistry C(sp3) centres along carbon skeleton. This review features synthetic methods that tackle this issue and strategically leverage control stereocentres complex organic molecules. Stereocentres can be created either initiation or termination site an process, retained during chain-walking across molecular backbone revealed through restructuring skeleton by selective ring-opening strained ring. As each these options imposes different mechanistic requirements, examples are divided according stage process established type intermediates lead stereodefined products. Remote popular strategy synthesis. typically Review outlines